Offenders broke into a house in Nethermead Court in Northampton and stole two puppies from a litter of seven that were with their mother.
The puppies are American Bulldog and Staffordshire Bull Terrier, and tan in colour.
The incident happened sometime between 4pm and 8pm on Wednesday, 26 April.
Anyone with information can contact Northamptonshire Police on 101. Alternatively, they can call the independent charity Crimestoppers anonymously on 0800 555 111.