Mr Netahyahu, who has been questioned several times since the start of 2017, is a suspect in two separate cases.
In one of them, he is alleged to have received $100,000 in gifts from Hollywood mogul Arnon Milchan and other wealthy supporters.
In the other case, he is accused of offering preferential treatment to a newspaper publisher in exchange for favourable coverage.
The 68-year-old has denied any wrongdoing and claims the recommendations “will end with nothing”.
In a televised address, he said he would “continue to lead Israel responsibly and faithfully”, describing the allegations as “baseless”.
His long-running political career had been solely “for the good of the nation”, he said.
In addition, he accused police of conducting a witch-hunt against him, and said he would run for re-election.
A decision on whether to press charges will be taken by Israel’s attorney general.