Cash and clothing were stolen by thieves when the Marie Curie charity shop on High Street, Kettering was broken into.
The offender(s) broke in sometime between 5.30pm on Tuesday, 10 November and 8.30am on Wednesday, 11 November.
DVDs and footwear were also stolen.
Anyone with any information can call Northamptonshire Police on 101. Alternatively, they can call the independent charity Crimestoppers anonymously on 0800 555 111.